Penelitian Toksisitas Subkronik Infus Daun Johar (Cassia siamea Lamk) pada Tikus Putih

Wahjoedi, B. and Nugroho, Yun Astuti and Winarno, Winarno and Pudjiastuti, Pudjiastuti (1996) Penelitian Toksisitas Subkronik Infus Daun Johar (Cassia siamea Lamk) pada Tikus Putih. Buletin Penelitian Kesehatan, 24 (4). ISSN 0125-9695

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Abstract

The Indonesia people still empirically use medicinal plants to overcome their diseases or maintain their health. One of the medicinal plants is Cassia siamea Lamk. (daun johar) used for treatment of fevers/malaria and jaundice/hepatitis. A lot of people usually use it for long periods of time. It is preferable for medicinal plants to have no effect rather than toxic effects. Subschronic toxicity test of the infusion of the leaf of Cassia Siamea Lamk, have been carried out on 72 female Wistar albino rats for4 months. The administration of the test materials were orally, every day except Sunday and there were three kinds of difference dosages respectively 25 mg/100 g b.w.; 250mg/100 g b.w. and 500 mg/100 g b.w. that means equivalent to 5 x; 25 x and 50 x usual dose of man. The control group received water only. The results showed that the infusion of the leaf of Cassia siamea Lamk. administered orally, every day until 4 months, the dose of up to 500 mg/100 g b.w. didn't show toxicological effect on the internal body organs pf the test animals such as liver, lung, spleen, kidney and intestine.

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