. Recurrent Aphtae Stomatitis (RAS) is a common disease with unknown specific etiology'. One of its predisposing factors is hormonal imbalance which is related to menstrual cycle Objective: To compare the women reproductive hormone level between RAS and non-RAS patients. Methods: A case control study involving women, 40 with RAS and 40 non-RAS from Oral Medicine Clinic, Faculty of Dentistry-Indonesia University was performed. The inclusion criteria were women within the reproductive age. Patients with any hormonal therapy, hysterectomy and ovarian-ectomy history were excluded. Patients were interviewed and the blood level of Estradiol, L.H., Prolactin, F.S.H were measured on the 7th day, and Progesterone was measured on the 21st day of the menstrual cycle. Results: The hormone level in both groups were within normal range for Estradiol (48-309 pg/ml), L. H (1 — 18 mlU/ml), Prolactine(1.39-24.2 ng/ml) and FSH(4 — 13 mlU/ml). A higher percentage of the women with RAS had a Progesterone hormone level lower than normal than that of women without RAS (72.5% vs 45%, OR p=0.013). From the interview it was apparent that family history of having RAS is significant in the RAS group compared to non-RAS.
Conclusion: Progesterone hormone level lower than normal is a predisposing factor for RAS in women.