This research is to find out basic information about risky behaviors in adolescents related to health and related factors. Location of the research conducted in Makassar with 10 randomly selected health centers of 14 districts. Samples were adolescent boys and girls aged between 10-24 years of either a married or unmarried who lived in the working area of the selected health centers. Using quantitative and qualitative approach in data collection, which for this article focused on the quantitative approach, which is conducted interviews of a number of 300 adolescents was selected as the sample through visits to the homes of respondents. Dependent variable of this study were adolescent risk behaviors measured by the factor of juvenile delinquency, smoking behavior, drinking alcohol, drug abuse, STDs, sexual behavior before marriage, and abortion. Whereas independent variables of the study were age, sex, education, occupation, daily activities, parental supervision, parents drank alcohol, the role of information media, and Domestic Violence. The study showed that there was a significant relationship between gender, education level, work status, parents drink alcohol, get domestic violence treatment, with risk behavior in adolescents. It is recommended to improve parental knowledge about child a good upbringing and the importance of maintaining harmony in the home, for example, by organizing seminars to parents, so that children feel comfortable, in order to reduce risk behavior in adolescents.