ISOLASI DAN IDENTIFIKASI SENYAWA KUMARIN DARI TANAMAN ARTEMISIAANNUA (L).

Isnawati, Ani and Mudahar, Harfia and Kamilatunisah, Kamilatunisah (2008) ISOLASI DAN IDENTIFIKASI SENYAWA KUMARIN DARI TANAMAN ARTEMISIAANNUA (L). Media Penelitian dan Pengembangan Kesehatan, 18 (3). pp. 107-118. ISSN 0853-9987

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Abstract

The invention of new entity from plant was the basic step for chemistry and another sciences development, such as: pharmacy, biology, and medical. Besides that, it is needed to fulfill people needs on food. medicine, cosmetics, etc. Coumarine is fenilpropanoid that has biological activity to stimulate skin pigmentation, influence enzyme activity, anti coagulant, anti microbial and inhibition of carcinogenic effect. One of the plants that contain coumarine is Artemisia annua L. because of that we interested in isolating coumarine and it's derivate in Artemisia annua L with expectation that study resulted in discovering anti cancer agent. The method that we use is extraction and soxhletation using methanol and fractionation using dichtoromethane. The separation was done by column Chromatography with silica gel and eluent n-hexane:etil acetate. Purification was done by recrystalization. Isolate is identified using KLT. GC-MS. Spectrophotometer UV. IR and NMR. This study shows that isolate was coumarine named 2H-l-Benzopyran-2-one, 7-hydroxy-6-methaxy or Scopoletin with molecular weight 192

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