Status Homocystein dan Folic Acid pada Ibu Hamil Anemia

Permaesih, Dewi (2001) Status Homocystein dan Folic Acid pada Ibu Hamil Anemia. Project Report. Center for Research and Development of Nutrition and Food, NIHRD.

Abstract

Background: Folic acid deficiency among pregnant women in Indonesia is quite prevalent. It is believed to cause the anemia and the risk of infant neural tube defect. Folic acid plays a certain role in homocystein convertion into methionine. Serum homocystein will increase with the decrease folic acid. Objective: To obtain folic acid consumption, homocystein and folic acid status in pregnant women suffering from anaemia using recent method of determination, and relationship of the three variables. Methodology: Pregnant women in the study area were screened by their Hb values under 11 g/dL. Thirty anemic pregnant women were further studied on their nutritional status, folic acid consumption, folic acid and homocystein status in serum. Folic acid consumption was obtained by used 2 x 24 hours recall method. Folic acid was analysed by Ion Capture Method and homocystein was analysed by Fluoresence Polarization Immuno assay. Results: Folic acid consumption was 61 + 50 ug/day. Average of serum folic acid was 7.53 + 2.8 ug/mL with a range of 3.5 to 15.1 ug/mL. Normal value of serum folic acid was 3.1 to 12.4 ug/mL. Therefore, the value of folic acid of pregnant women in this study was still in the range of normal value. Serum homocystein value in pregnant women was 7.1 + 1.95 ug/ml with a range of 3.0 to 10.9 ug/ml, while normal value was 5 to 15 ug/dL. Conclusion: Homocystein and folic acid status of pregnant women in this study was normal.

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