Dampak Pemberian Niasin dan Kromium terhadap Profil Dislipid pada Penderita Dislipidemia

Dahro, Ance Murdiana (1998) Dampak Pemberian Niasin dan Kromium terhadap Profil Dislipid pada Penderita Dislipidemia. Project Report. Center for Research and Development of Nutrition and Food, NIHRD.

Abstract

A study on niacin and chromium supplementation has been conducted to women of 30-60 years old with cholesterol level between 200-500 mg/dl. The aimed of the study was to see the effect of the supplementation on blood cholesterol, triglyceride and low density lipoprotein (LDL). Forty two respondents were selected purposively and divided into 4 groups. The supplementation was in the form of capsules and given for 3 weeks. Group I, 10 respondents received 200 mcg of chromium; Group II, 7 respondents received chromium 200 mcg and niacin 2 x 75 mg; Group III, 12 respondents received 2 x 75 mg niacin and Group IV, 13 respondents received 2 x 75 mg fructose as placebo. Data collected including anthropometrics, dietary recall for 1 x 24 hours and clinical status. Analysis of blood sample for cholesterol and triglyceride was done using enzymatic calorimetric method (CHOD-PAP) whereas LDL was done using PVS methods (GPO-PAP). The results of this study showed that niacin supplementation significantly decreased cholesterol and LDL level by 15 percent and 13 percent respectively, chromium supplementation significantly decreased cholesterol and LDL level by 15 percent and 20 percent respectively. Cholesterol and LDL remained in that level three weeks afterwards. The mixture of niacin and chromium supplementation significantly decreased only cholesterol level by 10 percent. Triglyceride level decreased in all groups including placebo group but not statistically significant.

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