Dissolution Profile And Determination Of Meloxicam Content In Innovator And Branded Generic Tablet By HPLC (High Performance Liquid Chromatography) Profil Disolusi Dan Penetapan Kadar Tablet Meloksikam Inovator Dan Generik Bermerek Dengan KCKT( Kromatografi Cair Kinerja Tinggi )

Mutiatikum, Daroham (2010) Dissolution Profile And Determination Of Meloxicam Content In Innovator And Branded Generic Tablet By HPLC (High Performance Liquid Chromatography) Profil Disolusi Dan Penetapan Kadar Tablet Meloksikam Inovator Dan Generik Bermerek Dengan KCKT( Kromatografi Cair Kinerja Tinggi ). Buletin Penelitian Kesehatan, 38 (3). pp. 140-146. ISSN 0125-9695

Abstract

The determination of meloxicam and the dissolution test has been done. Drug dissolution test is an approach to evaluate drug release characteristics of a product ( Tablets/capsules ) in vitro. The tests are conducted for various durations from 5,10,15,20,25,30,40,50 and 60 minutes with appropriate sampling. The method of dissolution test and assay of meloxicam accords with British Pharmacopoeia 2007. A control experiment with HPLC was performed simoultaneously. The dissolution test of meloxicam at 30 menites in tablet A is 97.79% and tablet B is 87.78 % meet the requirement of the British Pharmacopoeia 2007. The content of meloxicam are in tablet A is 100.26%, tablet B is 104.07%. Both of its meet the requirement of British Pharmacopoeia 2007.

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