Pengaruh Temperatur dan Waktu Penyimpanan terhadap Potensi Vaksin Polio Oral Trivalen (Sabin Type)

Yuwono, Djoko (1985) Pengaruh Temperatur dan Waktu Penyimpanan terhadap Potensi Vaksin Polio Oral Trivalen (Sabin Type). Buletin Penelitian Kesehatan, 13 (2). ISSN 0125-9695

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Abstract

The effect of temperature and duration of storage on the potency of trivalent oral polio vaccine (Sabin Type) were investigated. Temperature was set up at the beginning from :-20 degree celcius, 0 degree celcius, 5 degree celcius, 10 degree celcius, 15 degree celcius, 25 degree celcius and 30 degree celcius. During 30 days peroid of storage, the polio virus was titrated at 4 days interval using micromethod of TCID calculation in vero cells. The result of the study showed that the effect of -20 degree celcius, 0 degree celcius and 5 degree celcius for 30 days storage was not significantly different. Whereas at 10 degree celcius the vaccine potency had started to decrease at day 24 up to day 30. At 15 degree celcius the potency had started to decrease at day 12, while at 25 degree celcius and 30 degree celcius the potency of vaccine drooed sharply at day 4 of storage.

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